This lecture documents and explores efforts genome scientists and policy makers have made over the course of the last decade to transform human genomics from a science that raises fears about exploitation to one that promises anti-racist futures. It considers the novel problems that confront both genome scientists and subjects of genomic research alike as the goals of anti-racism and democratic values of inclusion and participation converge to explicitly shape the conceptualization and design of genomic research. Finally, it explores why many genome scientists, policy makers, and critical race theorists who seek to transform genomics into a liberal anti-racist practice miss these problems, and inadvertently contribute to the neo-liberalization of race—an ongoing process by which social struggles to counteract racism are replaced by individual efforts to negotiate entrance into racial categories for the purposes of securing resources.